Skin Barrier Response to Rapid Environmental Shifts: Modulation of Filaggrin and Aquaporin-3 in an Ex Vivo Model.

Author: Ana Lucia Pinheiro¹, Barbara Carli¹, Giovana Valim Albigesi¹, Kelen Fabiola Arroteia¹, Samir Eberlin², Carla Monserrat Grecco Lopes¹, Samara Eberlin¹

Published at: January 01, 1900

https://kosmoscience.com/pdf/skin-barrier-response-to-rapid-environmental-shifts-modulation-of-filaggrin-and-aquaporin-3-in-an-ex-vivo-model.pdf

Rapid and recurrent shifts in temperature and humidity are increasingly common in modern urban environments and may challenge skin homeostasis. As the primary interface with the environment, the epidermis is particularly vulnerable to these fluctuations, which can compromise barrier integrity and hydration. Although the effects of individual stressors such as heat, cold, and low humidity are well documented, the impact of abrupt and sequential environmental changes, which better reflect real-life exposure, remains poorly understood. These stressors can modulate thermosensitive TRP channels, inflammatory pathways, and epidermal differentiation, which potentially affecting key structural proteins and barrier function. However, their combined and sequential effects on epidermal biomarkers remain unclear.