Targeting Inflammation–Barrier Crosstalk: A Pre-Clinical Ex Vivo Study of a Cosmetic Formulation for Skin Comfort and Resilience

Author: Layane Melody da Silva Reis Cavalcante¹, Lucia de Fatima Holanda¹, Giulia Okamoto Maciente1, Mauricio Frazilho¹, Carla De Figueiredo Presti Favaro¹, Marisa Sacuragui¹, Gabriela da Silva Leite², Gustavo Henrique da Silva², Barbara de Freitas Carli², Carla Monserrat Grecco Lopes², Ana Lucia Tabarini Alves Pinheiro², Kelen Fabíola Arroteia², Samara Eberlin²

Published at: January 01, 1900

https://kosmoscience.com/pdf/targeting-inflammation-barrier-crosstalk-a-pre-clinical-ex-vivo-study-of-a-cosmetic-formulation-for-skin-comfort-and-resilience.pdf

Skin inflammation and barrier impairment are closely interconnected processes involved in skin sensitivity, discomfort, and premature aging. External aggressors can trigger inflammatory cascades, increasing interleukin-1 alpha (IL-1α) levels and activating nuclear factor kappa B (NF-κB). These responses may compromise epidermal barrier proteins, including filaggrin, and contribute to extracellular matrix degradation, affecting structural components such as collagen I. Barrier disruption may further facilitate irritant penetration, perpetuating inflammation and skin fragility. Therefore, simultaneously targeting inflammation, barrier integrity, and dermal structure represents a relevant strategy for maintaining skin homeostasis and resilience.